Discovery of chromeno”4,3-c”pyrazol-4(2H)-one containing carbonyl or oxime derivatives as potential,selective inhibitors PI3Kα

摘要：

　　A series of novel chromeno”4,3-c”pyrazol-4(2H)-one containing carbonyl or oxime derivatives(4a-4n,5a-5n)have been synthesized and evaluated their biological activities as PI3K inhibitors.Out of them,compound 5l showed the most potent antiproliferative activities against HCT-116 with IC50 of 0.10 μM in vitro,and exhibited the most potent activity for PI3Kα with the value of 0.012 μM.Docking simulation of 51 into PI3Kα active site were performed to determine the probable binding model,and it indicated that compound 5l could be optimized as a potential inhibitor of PI3Kα in the further study.

关键词： chromeno”4,3-c”pyrazol-4(2H)-one derivatives PI3Kα Antiproliferative

作者: Liang Lu Shao Sha Kai Wang Yuan-Heng Zhang Yan-Dong Liu Guo-Dong Ju Baozhong Wang Hai-Liang Zhu

作者单位: State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,People”s Republic of China

会议类型: 国内会议

会议名称: 第八届国际分子模拟与信息技术应用学术会议

会议地点: 大连

会议语种:英文

页码: 289-309

在线出版日期: 2016-09-24（万方平台首次上网日期，不代表论文的发表时间）