Design,synthesis and biological evaluation of novel Fluoroquinolone derivatives as potential,selective inhibitors of PI3Kγ

摘要：

Phosphoinosilide 3-kinase(PI3K) is an attractive target to potentially treat a range of disease stales as illustrated by more than 15 inhibitors now in clinical trials.We disclose herein the discovery of a new class of fluoroquinolone derivatives having improved potency toward PI3K.

作者: Shao Sha Hong-Wei Han Fei Gao Tian-Bao Liu Zhen Li Chi Xu Wei-Qing Zhong Hai-Liang Zhu

作者单位: State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,PR China School of Pharmacy,Second Military Medical University,Shanghai 200433,P.P.China State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,PR China;Scho

会议类型: 国内会议

会议名称: 第八届国际分子模拟与信息技术应用学术会议

会议地点: 大连

会议语种:英文

页码: 331-331

在线出版日期: 2016-09-24（万方平台首次上网日期，不代表论文的发表时间）