Discovery of novel indirubin-3”-monoxime derivatives as potent inhibitors against CDK2 and CDK9

摘要：

　　Indirubin-3”-monoxime(IM)is a potent cyclin-dependent kinase(CDK)inhibitor,Twenty novel IM derivatives were prepared to investigate the structure-activity relationships(SAR)of this compound class.Six compounds showed significant inhibition against both CDK2/cyclin E1 an CDK9/cyclin T1.The most potent compound 7t exhibited IC50 values at submicromolar level.Preliminary SAR trends were suggested and cytotoxicity of these compounds was investigated.Molecular docking studies on compounds 7l and 7t provided conducive clues for further structural optimization.

关键词： Indirubin-3”-oxime derivatives Cyclin-dependent kinase 2 Cyclin-dependent kinase 9 Structure-activity relationship

作者: Lei Yan Fangfang Lai Xiaoguang Chen Zhiyan Xiao

作者单位: Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation,Institute of Materi Beijing Key laboratory of New Drag Mechanisms and Pharmacological Evaluation Study,Institute of Mate

会议类型: 国内会议

会议名称: 第八届国际分子模拟与信息技术应用学术会议

会议地点: 大连

会议语种:英文

页码: 350-354

在线出版日期: 2016-09-24（万方平台首次上网日期，不代表论文的发表时间）