Inflammatory pathway network-based drug repositioning and molecular phenomics
Inflammationis a protective biological response to body/tissue damages that involves immune cells,blood vessels and molecular mediators.In this work,we constructed the pathway network of inflammation,including 11 sub-pathways of inflammatory factors.Pathway-based network efficiency and network flux were adopted to evaluate drug efficacy.By using approved and experimentally validated anti-inflammatory drugs as training sets,a predictive model was built to screen potential anti-inflammatory drugs from approved drugs in DrugBank.This drug repositioning approach would bring a fast and cheap way to find new indications for approved drugs.Moreover,molecular phenomics profiles ofthe expression of inflammatory factors willprovide new insight into drug mechanism of action.
Jiangyong Gu Philip S.Crosier Christopher J, Hall Lirong Chen Xiaojie Xu
Beijing National Laboratory for Molecular Sciences,Stale Key Lab of Rare Earth Material Chemistry an Department of Molecular Medicine and Pathology,School of Medical Sciences,University of Auckland,Auc
国内会议
大连
英文
439-451
2016-09-24（万方平台首次上网日期，不代表论文的发表时间）