Synthesis,Molecular Modeling,and Biological Evaluation of Novel 1,3-Diphenyl-2-propen-1-one Based Pyrazolines as Anti-inflammatory Agents
A novel series of 1,3-diphenyl-2-propen-1-one(chalcone)derivatives was synthesized by a simple,ecofriendly,and efficient Claisen-Schmidt condensation reaction and used as precursors for the synthesis of new pyrazoline derivatives.All the synthesized compounds were screened for anti-inflammatory related activities such as inhibition of phospholipase A2(PLA2),cyclooxygenases(COX-1 and COX-2),IL-6,and TNF-α.The results of the above studies show that the compounds synthesized are effective inhibitors of above pro-inflammatory enzymes and cytokines.Over-alt,the results of the studies reveal that the pyrazolines with chlorophenyl substitution(1b-6b)seem to be important for inhibition of enzymes and cytokines.Molecular docking experiments were performed to clarify the molecular aspects of the observed COX-inhibitory activities of the investigated compounds.
arachidonic acid chalcones Claison-Schmidt condensation flavonoids lipopolysaccharides
Syed Nasir Abbas Bukhari Xin Zhang Ibrahim Jantan Hai-Liang Zhu Muhammad Wahab Amjad Vijay H.Masand
Drug and Herbal Research Centre,Faculty of Pharmacy,Universiti Kebangsaan Malaysia,Jalan Raja Muda A Institute of Functional Biomolecutes,State Key Laboratory of Pharmaceutical Biotechnology,Nanjing Un Department of Chemistry,Vidya Bharati Mahavidyalaya,Amravati,Maharashtra 444 602,India
国内会议
大连
英文
957-970
2016-09-24（万方平台首次上网日期，不代表论文的发表时间）