The Role of Propofol Hydroxyl in Anesthetic-Protein Targeting Molecular Recognition:ONIOM Studies

摘要：

Propofol(1-hydroxyl-2,6-diisopropylbenzene,PFL)is well known as the most widely used intravenous general anesthetic for the induction and maintenance of anesthesia.To assess the significance of the 1-hydroxyl in propofol for anesthetic efficacy in vitro and in vivo,a compound 1-fluoro-,6-diisopropylbenzene,referred to as ”fropofol(FFL)” to emphasize their characteristics in parallel with those of PFL in terms of molecular volume and hydrophobicity,was synthesized and studied recently”1”.

作者: Ling Qiu Shanshan Wang Xueyu Zhao Jianuo Lin

作者单位: Key Laboratory of Nuclear Medicine,Ministry of Health & Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,P.R.China;School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,P.R.China

会议类型: 国内会议

会议名称: 第八届国际分子模拟与信息技术应用学术会议

会议地点: 大连

会议语种:英文

页码: 1014-1015

在线出版日期: 2016-09-24（万方平台首次上网日期，不代表论文的发表时间）