Encephalomyocarditis Virus 3C Protease relieves TANK Inhibitory Effect on TRAF6-mediated NF-kappaB Signaling through Cleavage of TANK

摘要：

　　TRAF family member-associated NF-κB activator(TANK)is a negative regulator of canonical NF-κB signaling in the Toll-like receptor(TLR)-and B-cell receptor(BLR)-mediated signaling pathways.However,functions of TANK in viral infection-mediated NF-κB activation remain unclear.Here we reported that TANK was cleaved by encephalomyocarditis virus(EMCV)3C at the 197 and 291 glutamine residues, which depends on its cysteine protease activity.In addition,EMCV 3C impaired the ability of TANK to inhibit TRAF6-mediated NF-κB signaling.Interestingly,we found that several viral proteases encoded by foot and mouth diseases virus(FMDV),porcine reproductive and respiratory syndrome virus(PRRSV)and equine arteritis virus(EAV)also cleaved TANK.Our results suggest that TANK is a novel target of some viral proteases,indicating that some positive RNA viruses have evolved to utilize their major proteases to regulate NF-κB activation.

关键词： encephalomyocarditis virus 3C protease cleavage TANK TRAF6 NF-κB

作者: Li Huang Qinfang Liu Lijie Zhang Quan Zhang Liang Hu Changyao Li Shengnan Wang Jiangnan Li Yuanfeng Zhang Huibin Yu Yan Wang Zhaohua Zhong Tao Xiong Xueshan Xia Xiaojun Wang Li Yu Guohua Deng Xuehui Cai Shangjin Cui Changjiang Weng

作者单位: State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute of Chinese Aca State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute of Chinese Aca State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute of Chinese Aca Department of Microbiology,Harbin Medical University,Harbin,China College of Life Sciences,Yangtze University,Jingzhou,China Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming,China

会议类型: 国内会议

会议名称: 中国畜牧兽医学会生物技术学分会暨中国免疫学会兽医免疫分会第十二次学术研讨会

会议地点: 昆明

会议语种:英文

页码: 184-204

在线出版日期: 2016-11-01（万方平台首次上网日期，不代表论文的发表时间）