GABA mediates interleukin-17 expression during intestinal bacterial infection

摘要：

　　Interleukin-17(IL-17)has a central role against bacterial pathogens in the intestine.However,the mechanism by which intestinal IL-17 expression is triggered during bacterial infection is poorly understood.Here,we found enterotoxigenic Escherichia coli(ETEC)increases intestinal IL-17 expression through γ-aminobutyric acid(GABA)signaling,which largely depends on intestinal GABA-producing Lactococcus lactis subsp.lactis.GABA promotes intestinal IL-17 expression in the context of ETEC infection through enhancing mTOR signaling,which activated ribosomal protein S6 kinase 1(S6K1)-early growth response protein 2(EGR2)-growth factor independent 1 transcription repressor(GFI1)pathway.GABAmTOR signaling also affected IL-17 expression in response to Citrobacter rodentium infection and in drug-induced models of intestinal inflammation.Furthermore,a deficiency of slc6a13(GABA transporter 2)in mice promotes Th17 responses against intestinal infection.These findings highlight the importance of GABA-mTOR signaling in intestinal IL-17 expression during intestinal infection,and indicate the potential of GABA signaling in IL-17-associated intestinal diseases.

关键词： GABA IL-17 mTOR enterotoxigenic Escherichia coli Lactococcus lactis

作者: Ren wenkai Liu gang Tan bie Li tiejun Wu guoyao Philip R.Hardwidge Yin yulong

作者单位: Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology,Institute of Subtropica Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology,Institute of Subtropica Department of Animal Science,Texas A&M University,2471 TAMU,College Station,TX,77843-2471,USA Department of Diagnostic Medicine/Pathobiology,Kansas State University,Manhattan,KS 66506,USA

会议类型: 国内会议

会议名称: 第七届中国畜牧科技论坛

会议地点: 重庆

会议语种:英文

页码: 3-20

在线出版日期: 2016-05-25（万方平台首次上网日期，不代表论文的发表时间）