Andrographolide inhibits intracellular Ca2+release and caveolin-1 expression in myocardial microvascular endothelial cells

摘要：

　　The aim of this study was to investigate the effect of Andrographolide(ANDRO)on intracellular Ca2+release and the expression of caveolin-1(CAV1)in rat microvascular endothelial cells(RMMECs)and the underlying mechanism.We observed that ANDRO significantly inhibited extracellular ATP(eATP)-induced Ca2+release in primary RMMECs.In addition,ANDRO also exhibited inhibitory activity both on the mRNA and protein expression of phospholipase Cδ3(PLCδ3)and CAV1.We conclude that ANDRO reduced the expression of CAV1 and eATP-induced transient calcium release at least partially by decreasing the expression of PLCδ3.Our findings provide some insights into the mechanisms by which ANDRO can alter molecules involved in atherosclerosis(As).

关键词： andrographolide microvascular endothelial cells calcium caveolin-1 phospholipase Cδ3

作者: Bo Feng Qian Zhang Ying Gao Xin Wang Xiangwan Sun Yun Wang Xiang Mu Hong Dong

作者单位: Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture, Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture, Tennessee Center for Botanical Medicine Research,Department of Biology,Middle Tennessee State Univer

会议类型: 国内会议

会议名称: 第七届中国畜牧科技论坛

会议地点: 重庆

会议语种:英文

页码: 1254-1262

在线出版日期: 2016-05-25（万方平台首次上网日期，不代表论文的发表时间）