Preparation and characterization of silver nanoparticles composited on polyelectrolyte film coated sericin gel for enhanced antibacterial application
Sericin has shown a great potential as a biomaterial in biomedical application due to its good hydrophilicity,reactivity and biodegradability.To solve the adherence and growth of microorganisms on sericin gel,here we prepared a polyelectrolyte film with interactive arrangement of opposite charges poly(dimethyldiallylammmonium chloride)(PDDA)and poly(acrylic acid)(PAA)coated on the surface of sericin gel via electrostatic interaction.AgNPs was then synthesized with the assistance of UV in situ on the polyelectrolyte film to endow the antibacterial activity of sericin gel.SEM revealed the polyelectrolyte film could effectively facilitate the high density growth of AgNPs as a 3-D matrix and the modification of polyelectrolyte and AgNPs did not alter the porous characteristics of sericin gel.XRD studies suggested AgNPs synthesized on polyelectrolytes film coated sericin gel had good crystal structure.DSC analysis showed AgNPs could form tight binding with polyelectrolytes film and sericin gel,and the binding may alter the melting temperature of AgNPs.Both bacterial inhibition zone and growth curve assay demonstrated AgNPs-polyelectrolytes film coated sericin gel had an excellent and long-lasting antibacterial activity.This novel sericin gel has shown great potentials in biomedical application such as wound healing.
sericin gel silver nanoparticles polyelectrolyte film antibacterial application
Gang Tao Yejing Wang Lina Liu Huaipu Chang Ping Zhao Huawei He
State Key Laboratory of Silkworm Genome Biology,Southwest University,Beibei,Chongqing 400715,China State Key Laboratory of Silkworm Genome Biology,Southwest University,Beibei,Chongqing 400715,China;C Chongqing Engineering and Technology Research Center for Novel Silk Materials,College of Biotechnolo State Key Laboratory of Silkworm Genome Biology,Southwest University,Beibei,Chongqing 400715,China;C
国内会议
重庆
英文
1848-1858
2016-05-25（万方平台首次上网日期，不代表论文的发表时间）