Analysis of Lathyrane Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance

摘要：

　　A series of lathyranediterpeneswere isolated or synthesized,and established on the basis of extensive spectroscopic methods,including two-dimensional NMR techniques.Stereo configuration and conformation of Euphorbia factors L1,L2,L7a,L7b,L8and derivatives of L3were analyzed by X-ray diffraction for the first time.The configuration of the unique isolathyrolditerpeneEuphorbia factorL7bwas rectified from S* to R* at C-5.All compounds were examined as modulators of multidrug resistance on MCF-7/ADM cell lines in vitro.To obtain sufficient information on the structural characteristics of this class of compounds,the detailed fragmentation patterns of the lathyranediterpenes were studied with collision-induced dissociation(CID)–MS/MS using an ESI–quadrupole time-of-flight(QTOF)–MS/MS hybrid instrument in positive-ion mode.

作者: Wei Jiao Xiaozhen Chen Dongmei Fang Runhua Lu Huawu Shao

作者单位: Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041

会议类型: 国内会议

会议名称: 中国化学会第十九届全国有机分析及生物分析学术研讨会

会议地点: 成都

会议语种:英文

页码: 263-264

在线出版日期: 2017-03-30（万方平台首次上网日期，不代表论文的发表时间）