Spirostanols from the roots and rhizomes of Trillium tschonoskii and their cytotoxic activities
Two novel spirostanols, (23S,24R,25S)-18-norspirost-1,4,13-triene-21,23,24-triol-3,15-dione (1) and (23S,24S,25S)-spirost-5-ene-1β,3β,21,23,24-pentaol (2), and a new natural product (3), together with two known analogues (4 and 5) were isolated from the ethyl acetate-soluble portion of the ethanolic extract of Trillium tschonoskii Maxim.Their structures were elucidated by extensive spectroscopic analyses,and their cytotoxic activities on four kinds of human tumor cells were studied in vitro.Compound 4 showed significant cytotoxic activity against A549 and MCF-7 with the IC50 values of 6.16 ±2.21 and 28.5 ± 11.5uM, respectively,while 5 exhibited selective cytotoxicity against A549 with an IC50 values of 13.0±4.51 uM.
Trillium tschonoskii Liliaceae spirostanols 18-norspirostanols cytotoxic activity
Chun-Wang Meng Cheng Peng Qin-mei Zhou Huai Yang Li Guo Liang Xiong
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Me Key Laboratory of Standardization of Chinese Herbal Medicine of the Ministry of Education, Pharmacy
国内会议
世界中医药学会联合会道地药材多维评价专业委员会成立大会暨第一届学术年会
成都
英文
49-56
2015-10-01（万方平台首次上网日期，不代表论文的发表时间）