Natural products inspired asymmetric synthesisofbio-activeγ-lactonesvia organocatalyticcascade reactions

摘要：

　　A sequential asymmetric organocatalysis tandem reaction catalyzed by NHC and amine together has been developed to assemble aromatic aldehydes and enals into chiral tetrahydrofuran derivatives bearing multiple functional groups and stereogenic centers with high stereoselectivity of up to 95∶5 dr and 96% ee.The high yield and stereocontrol of this process may be due to acid-promoted both symmetrisation of racemic acyloins and iminium ion activation of enals.

关键词： γ-lactones asymmetric organocatalysis cascade reactions

作者: Xianghong He Qian Zhao Bo Han Cheng Peng

作者单位: State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources,School of Pharmacy, Chengdu University of Traditional Chinese Medicine,Chengdu 611137,People”s Repubblic of China

会议类型: 国内会议

会议名称: 世界中医药学会联合会道地药材多维评价专业委员会成立大会暨第一届学术年会

会议地点: 成都

会议语种:英文

页码: 57-63

在线出版日期: 2015-10-01（万方平台首次上网日期，不代表论文的发表时间）