基于沉默基因簇激活的海洋天然产物生物合成
Genome sequences of actinomycetes have clearly demonstrated a large number of biosynthetic gene clusters potentially coding for natural products.However,most gene clusters remain cryptic.This fact prompts the concept of genome mining by developing diverse strategies to awaken those”silent”gene clusters to produce substantial amounts of natural products for structure elucidation and bioactivity evaluation,such as the change of cultivation parameters,ribosome engineering,replacement of promoters,overexpression of pathway-specific activators,and synthetic biology-guided pathway reconstitution.The success of these approaches has accelerated microbial natural product discovery and made a renaissance for interests of pharmaceutical industries in actinomycetes.
海洋天然药物 生物合成 结构多样化 生物学功能
张长生
中国科学院南海海洋研究所
国内会议
浙江舟山
中文
4-4
2015-10-01（万方平台首次上网日期，不代表论文的发表时间）