High LDH1 expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia
The prognostic value of IDH1 mutations has been systematically evaluated in acute myeloid leukemia (AML) patients recently.However, the role of IDH1 expression in AML is still under exploration.To investigate the clinical significance, we analyzed the IDH1/2 expression in 320patients with cytogenetically normal AML (CN-AML) by quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR).High expression of IDH1 was predominant in patients with FLT3-ITD and DNMT3A mutations, and less prevalent in cases with CEBPA double allele mutations.Strong association was observed between high IDH1 expression and low expression of microRNA 181 family.Prognosis was adversely affected by high IDHI expression with shorter overall survival (OS) and event free survival (EFS) in the context of clinical characteristics including age, WBC, and gene mutations of NPMI, FLT3-ITD, CEBPA,IDH1, IDH2, and DNMT3A in CN-AML.Moreover, the clinical outcome of IDH1 expression in terms of OS, EFS and complete remission rate still remained in multivariate models in CN-AML.Importantly, the prognostic value was validated using the published microarray data from 79 adult patients treated according to the German AMLCG-1999 protocol.Our results demonstrated that high IDH1 expression is associated with a poor prognosis of CN-AML.
Qiu-Ling Ma Jing-Han Wang Yun-Gui Wang Chao Hu Qi-Tian Mu Meng-Xia Yu Lei Wang Dong-Mei Wang Min Yang Xiu-Feng Yin Fei-Fei Chen Sha-Sha Lu Jian Chen Zhi-Juan Zhu Sai-Juan Chen Jie Jin
Department of Hematology & Institute of Hematology, The First Affiliated Hospital, Zhejiang Universi Department of Hematology & Institute of Hematology, The First Affiliated Hospital, Zhejiang Universi Department of Hematology & Institute of Hematology, The First Affiliated Hospital, Zhejiang Universi State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affilia
国内会议
河南省中医、中西医结合学会血液病分会第二届第二次学术会议暨肿瘤生物免疫治疗新进展学术会
郑州
英文
115-126
2015-12-19（万方平台首次上网日期，不代表论文的发表时间）