INHIBITION OF THREE NOVEL RADIX SCUTELLARIAE EXTRACTS ON IMMEDIATE HYPERSENSITWITY
Background: Radix Scutellariae, a few papers reported its pharmacology activities including alleviate small intestines smooth muscles spasm,sedation, antihypertensive effect.However, the inhibition of its different organic extracts on immediate hypersensitivity has not bee researched.Materials and Methods: To investigate the anti-immediate hypersensitivity of three extracts including ethanol extracts, acetone extracts, ethyl acetate extracts from Radix Scutellariae, four pharmacological screening model were chose, such as 4-Aminopyridine induced pruritus model, histamine-induced mouse paw edema model, PCA(passive cutaneous anaphylaxis) in ear of mouse, activie cutaneous anaphylaxismouse (mouse ear edema test), furthermore, total IgE level in the sensitized mice serum was evaluated deeply.Results: Ethanol group at 1.42g/kg and 0.71g/kg could greatly decrease the licking number to 1.2 and 12.7 respectively;also keep mice paw swelling at 0.29ml and 0.51ml at 15 min after injection of histamine.Both ear passive cutaneous allergic reaction and active cutaneous anaphylaxis-ear swelling test demonstrated that ethanol group exhibit great inhibition on immediate hypersensitivity.Low IgE level was found in ethanol group, but high in other two groups.Conclusion: The ethanol extracts exhibits obvious strong inhibition, however, the acetone ones and ethyl acetate showed a little.
Radix Scutellariae Ethanol extracts Anti-allergic activity PCA IgE level
Xiaorong Li Jiangning Wang Haiyun Shi Lei Gao Xueyan Wang
Central Laboratory, The Luhe Teaching Hospital of the Capital Medical University, Beijing, China Reparative and reconstructive Sugery, Beijing Shijitan Hospital, Capital Medical University Beijing, Department of Allergy,Beijing Shijitan Hospital, Capital Medical University, Beijing, China 4Plastic Surgery, The Luhe Teaching Hospital of the Capital Medical University, Beijing, China
国内会议
北京
英文
409-415
2015-10-31（万方平台首次上网日期，不代表论文的发表时间）