Tcell immune abnormalities in immune thrombocytopenia
Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity.Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition.The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia.The induction of T cell tolerance is an important mechanism by which the pathogenesis and treatment of immune thrombocytopenia can be studied.Studies regarding the roles of the new inducible costimulator signal transduction pathway, the ubiquitin proteasome pathway, and the nuclear factor kappa B signal transduction pathway in the induction of T cell tolerance can help improve our understanding of immune theory and may provide a new theoretical basis for studying the pathogenesis and treatment of immune thrombocytopenia.
immune thrombocytopenia T cell immune tolerance pathogenesis
Xuebin Ji Ming Hou
Department of Hematology, Qilu Hospital of Shandong University, Jinan, China PR
国内会议
济南
英文
119-120
2015-06-05（万方平台首次上网日期，不代表论文的发表时间）