FZD7 is elevated in CML and regulates sensitivity of CML cells to imatinib in a co-culture system with BMSCs

摘要：

Objective:To detect the expression of FZD7 in CML CD34+ cells compared to normal CD34+ cells; To investigate the alteration of FZD7 and other Wnt/β-catenin signaling moleculars in CML cells after co-culture with BMSCs derived from both normal and CML bone marrow.To study the effect of FZD7 downregulation on proliferation and imatinib sensitivity in leukemic cells.To reveal the role of FZD7 in mediating a bond between BMSCs and CML cells, providing the basis for molecular targeted therapy.

作者: Na Liu Shaolei Zang Qiang Liu Peng Li Min Ji Jingjing Ye Xiulian Sun Daoxin Ma Chunyan Ji

作者单位: Department of Hematology, Qilu Hospital,Shandong University, Ji”nan 250012 National Key Lab of Otolaryngology, Qilu Hospital,Shandong University, Ji”nan 250012

会议类型: 国内会议

会议名称: 山东省抗癌协会第五次会员代表大会暨山东省第四届肿瘤学术大会

会议地点: 济南

会议语种:英文

页码: 201-203

在线出版日期: 2015-06-05（万方平台首次上网日期，不代表论文的发表时间）