Rhein reduces fat weight in db/db mouse and prevents diet-induced obesity in C57BL/6 mouse through the inhibition of PPARγ signaling
Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine.However, the components of rheum palmatum that play the anti-obesity role are still uncertain.Here, we tested the weight-reducing effect of two major rheum palmatum compounds on db/db mouse.We found that rhein (100 mg kg-1day-1), but not emodin, reduced the fat weight in db/db mouse.Using diet-induced obese (DIO) C57BL/6 mice, we identified that rhein blocked high-fat diet-induced obesity, decreased fat mass and the size of white and brown adipocytes, lowered serum cholesterol, LDL-cholesterol and fasting blood glucose levels in the mice.To elucidate the underlying mechanisms, we used reporter assay and gene expression analysis, and found that rhein inhibited peroxisome proliferator-activated receptor γ(PPARγ) transactivity and the expression of its target genes,suggesting that rhein may act as a PPARγ antagonist.Our data indicate that rhein maybe a promising choice for anti-obesity therapy.
Rhein obesity PPARγ db db mouse
Yu Zhang Shengjie Fan Na Hu Ming Gu Chunxiao Chu Yiming Li Xiong Lu Cheng Huang
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Scientific Experimental Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203
国内会议
上海
英文
314-326
2014-09-01（万方平台首次上网日期，不代表论文的发表时间）