SUDS3HDAC1 complex is required for maintenance of genomic imprinting and X chromosome inactivation during preimplantation development

摘要：

The fusion of oocyte and sperm initiate remarkable dynamic changes of epigenetic modifications throughout preimplantation development.Epigenetic events, including genomic imprinting and X chromosome inactivation (Xi), are fine-tuned during this stage to ensure successful development.To assess the role of SUDS3/HDAC1 complex in genomic imprinting/Xi, we performed loss-of-function via RNAi in mouse preimplantation embryos.

作者: Tong Liu Kun Zhang Jesse Mager

作者单位: Laboratory of Mammalian Molecular Embryology, College of Animal Sciences, Zhejiang University Department of Veterinary and Animal Sciences, University of Massachusetts at Amherst, Amherst, Massa

会议类型: 国内会议

会议名称: 第九次全国动物生物技术学术研讨会

会议地点: 陕西杨凌

会议语种:英文

页码: 135-135

在线出版日期: 2015-12-23（万方平台首次上网日期，不代表论文的发表时间）