Near-infrared fluorescence heptamethine carbocyanine dye imaging and targeted drug delivery for brain tumors in xenograft model

摘要：

Background Brain tumors are inherently difficult to access due to the cellular blood-brain barrier (BBB) and blood-tumor barrier (BTB) that limit the delivery of contrast and therapeutic agents to tumor tissues from the systemic circulation”1,2”.Near-infrared (NIR) heptamethine cyanine fluorescence dyes have emerged as promising tools for noninvasive cancer imaging ”3, 4”o These NIR agents show preferential uptake in tumor cells but not normal cells as demonstrated in a variety of cancer cell lines, tumor xenografts, spontaneous mouse tumors in transgenic animals and human tumor samples ”5, 6”.

作者: Changhong Shi Jason Boyang Wu Qinlong Li Ningning Zhao Caiqin Zhang Haiyen E.Zhau Leland W.K.Chung

作者单位: Lab animal center, the Fourth Military Medical University, Xi”an, 710032, China Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA

会议类型: 国内会议

会议名称: 第七届北京实验动物科学国际论坛

会议地点: 北京

会议语种:英文

页码: 149-153

在线出版日期: 2015-06-14（万方平台首次上网日期，不代表论文的发表时间）