15d-Prostaglandin J2 Protects Cortical Neurons Against Oxygen-Glucose Deprivation/Reoxygenation Injury:Involvement of Inhibiting Autophagy Through Upregulation of Bcl-2

摘要：

We have previously shown that PPAR-c agonist 15d-PGJ2 inhibited neuronal autophagy after cerebral ischemia/reperfusion injury.However,the underlying mechanism of its regulatory role in neuronal autophagy remains unclear.This study was designed to test the hypothesis that 15d-PGJ2 upregulated Bcl-2 which binds to Beclin 1,and thereby inhibits autophagy.We performed cell viability assay,cytotoxicity assay,western blot,and co-immunoprecipitation to analyze autophagy activities in vitro model of OGD/R.PPAR-c agonist 15d-PGJ2 exerts neuroprotection partially via inhibiting neuronal autophagy after OGD/R injury.

作者: 秦海东

作者单位: 南京市第一医院急诊医学科

会议类型: 国内会议

会议名称: 中华医学会灾难医学分会第三届年会暨城市安全与灾难医学救援国际高峰论坛

会议地点: 上海

会议语种:英文

页码: 25-25

在线出版日期: 2015-10-23（万方平台首次上网日期，不代表论文的发表时间）