Emerging role of long noncoding RNAs in autoimmune diseases
Long noncoding RNA(lncRNA),with size larger than 200 nucleotides,is a new class of noncoding RNA.Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity.Herein,we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease.In addition,we focus on the involvement of lncRNA regulation in innate and adaptive immune responses,immune cell development,and differential expression of lncRNAs in autoimmune diseases,including systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),type 1 diabetes mellitus(T1DM),multiple sclerosis(MS),autoimmune thyroid disease(AITD),psoriasis,polymyositis/dermatomyositis(PM/DM)and Crohn”s disease(CD).
lncRNA Noncoding RNA Immune function Autoimmunity Autoimmune disease
Guo-Cui Wu Hai-Feng Pan Rui-Xue Leng De-Guang Wang Xiang-Pei Li Xiao-Mei Li Dong-Qing Ye
Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,81 Mei Department of Nephrology,The Second Affiliated Hospital of Anhui Medical University,678 Furong Road, Department of Rheumatology and Immunology,Anhui Provincial Hospital,Affiliated to Anhui Medical Univ
国内会议
重庆
英文
83-90
2015-08-19（万方平台首次上网日期，不代表论文的发表时间）