Vitamin D in ankylosing spondylitis: Review and meta-analysis
Background: The role of vitamin D in ankylosing spondylitis(AS)is largely unknown.This paper aims to examine the association between serum vitamin D levels and susceptibility and disease activity of AS.Methods: We searched the relevant literatures in PubMed,Elsevier Science Direct,Chinese Biomedical Database(CBM),Chinese National Knowledge Infrastructure(CNKI)and Wanfang(Chinese)Database published before June 2014.Eight independent case–control studies with a total of 533 AS patients and 478 matching controls were selected into this meta-analysis.Standard mean differences(SMDs)with 95%confidence intervals(CIs)were used to assess the levels of serumvitamin D,parathyroid hormone(PTH),serumcalciumand alkaline phosphatase(ALP)in cases and controls,respectively.Correlation coefficients(CORs)have been performed to value the correlationship between vitamin D and disease activity(erythrocyte sedimentation rate(ESR)and Creactive protein(CRP)and Bath Ankylosing Spondylitis Disease Activity Index(BASDAI))of AS patients.Results: Meta-analysis results suggested that vitamin D may play a protective role in AS(for total vitamin D: SMD=-0.71,P b 0.001; for 25OHD: SMD=-0.66,P= 0.002; for 1,25OHD: SMD=-0.72,P= 0.19).Differences in PTH and serum calcium levels were not significant in AS(SMD = -0.10,P = 0.67; SMD = 0.12,P = 0.17 respectively),while ALPwas associatedwith AS susceptibility(SMD= 0.20,P= 0.04).The relationship between serum vitamin D levels and disease activity was statistically significant except for 25OHD versus(vs.)CRP or BASDAI(for CRP vs.25OHD: COR = -0.22,P = 0.08; for BASDAI vs.25OHD: COR =-0.20,P = 0.06,respectively).Conclusion: The higher levels of serum vitamin D were associated with a decreased risk of AS,and showed an inverse relationship with AS activity.
Ankylosing spondylitis Serum vitamin D Disease activity Meta-analysis Systemic inflammation Alkaline phosphatase
Guoqi Cai Li Wang Dazhi Fan Lihong Xin Li Liu Yanting Hu Ning Ding Shengqian Xu Guo Xia Xingzhong Jin Jianhua Xu Yanfeng Zou Faming Pan
Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,81 Mei Department of Rheumatism and Immunity,The First Affiliated Hospital of Anhui Medical University,Hefe Menzies Research Institute Tasmania,University of Tasmania,Private Bag 23,Hobart,TAS 7000,Australia
国内会议
重庆
英文
128-134
2015-08-19（万方平台首次上网日期，不代表论文的发表时间）