Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis
(0) Objectives: The results of studies on association between KIR(killer cell immunoglobulin-like receptors)polymorphisms and susceptibility to RA(rheumatoid arthritis)are inconsistent.To comprehensively evaluate the effect of KIR polymorphisms on the risk of RA,a meta-analysis was carried out.Methods: The Web of Science,PubMed,the Chinese Biomedical Database(CBM)and Chinese National Knowledge Infrastructure(CNKI)databases were systematically searched to select studies on the association between KIR polymorphisms and RA.The odds ratio(OR)with 95%confidence interval(95%CI)was obtained.Results: Nine qualified case–control studies were included in this meta-analysis.The results showed there were two positive associations of 2DL1,2DS1(OR2DL1 = 2.20,95%CI = 1.20–4.01,Praw = 0.01,PFDR = 0.03; OR2DS1 = 1.84,95%CI = 1.19–2.85,Praw = 0.006,PFDR = 0.018)and one negative association of 2DL3(OR2DL3 = 0.42,95%CI = 0.22–0.79,Praw = 0.006,PFDR = 0.018)with susceptibility to RA in East Asians,but not in Caucasians.Conclusion: The current meta-analysis provides evidence that 2DL3 might be a potential protective factor and 2DL1,2DS1 might be risk factors for RA in East Asians but not in Caucasians.
Killer cell immunoglobulin-like receptors Meta-analysis Polymorphisms Rheumatoid arthritis
Xiaona Li Qing Xia Dazhi Fan Guoqi Cai Xiao Yang Li Wang Lihong Xin Ning Ding Yanting Hua Li Liu Shengqian Xu Jianhua Xu Kang Wang Faming Pan
Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,81 Mei Department of Rheumatism and Immunity,The First Affiliated Hospital of Anhui Medical University,Hefe
国内会议
重庆
英文
195-200
2015-08-19（万方平台首次上网日期，不代表论文的发表时间）