我眼中的生物信息学

摘要：

Association study in infection，Infection disease exert evolution pressure inhuman population，Malaria and sickle-cell anaemia risk allele，Advantage of association study，Linkage analysis need multiple affected and unaffected relatives，Family-based, case-control or cohort data，Fine localization and identification of causative lociwith high-throughout technology，GWAS-basic analysis，GWAS-advanced analysis.TLR (Toll-like receptors) history.Toll:function in the embryonic dosal-ventraldevelopment of Drosophila (1988, cell 52:269).Drosophila with a loss of function mutation for Tollexhibits a high susceptibility to fungal infection(1996, cell 86:973).TLR: the so-called Toll-like receptors, humanhomolog genes for Toll(1997, 1998).TLR4 is the LPS sensor in both mice and humans(1998, Science 282:2085).Inflammatory caspases are innate immune receptorsfor intracellular LPS (2014, Nature 514:187).

关键词： 生物信息学 数据库 大数据时代

作者: 蔡涛

会议类型: 国内会议

会议名称: 2015第六届中国数据库技术大会(DTCC)

会议地点: 北京

会议语种:中文

页码: 1-45

在线出版日期: 2015-04-16（万方平台首次上网日期，不代表论文的发表时间）