Protective Effects of Thrombopoietin on Cerebral Ischemia-reperfusion in Rats

BACKGROUND: Thrombopoietin is not only involved in hematopoiesis, but also has protective effects on nervous system.This study aimed to investigate the protective effects and the mechanism of thrombopoietin (TPO) on cerebral ischemia-reperfusion in rats.METHODS: Thread embolism was performed to establish cerebral ischemia-reperfusion model in rats.Sixty SD rats were divided into TPO group, ischemia reperfusion group, sham operation group and normal group randomly.The TPO was given to TPO group at the beginning of ischemia at a dose of 5 μg/kg.Ischemia-reperfusion group was given isodose physiological saline.6, 12, 24 and 48 h after reperfusion, and the rats were executed and the brain tissues were cut into sections for HE staining and theimmunohistochemical staining to detect Bcl-2 and apoptosis.
C.L.Zou W.J.Chen X.S.Sun J.Fang J.Tu Y.Z.Zhao
Department of Internal Medicine, the Second People”s Hospital of Jingzhou, Jingzhou, China
国内会议
苏州
英文
336-336
2015-09-11(万方平台首次上网日期,不代表论文的发表时间)