会议专题

Protective Effects of Thrombopoietin on Cerebral Ischemia-reperfusion in Rats

BACKGROUND: Thrombopoietin is not only involved in hematopoiesis, but also has protective effects on nervous system.This study aimed to investigate the protective effects and the mechanism of thrombopoietin (TPO) on cerebral ischemia-reperfusion in rats.METHODS: Thread embolism was performed to establish cerebral ischemia-reperfusion model in rats.Sixty SD rats were divided into TPO group, ischemia reperfusion group, sham operation group and normal group randomly.The TPO was given to TPO group at the beginning of ischemia at a dose of 5 μg/kg.Ischemia-reperfusion group was given isodose physiological saline.6, 12, 24 and 48 h after reperfusion, and the rats were executed and the brain tissues were cut into sections for HE staining and theimmunohistochemical staining to detect Bcl-2 and apoptosis.

C.L.Zou W.J.Chen X.S.Sun J.Fang J.Tu Y.Z.Zhao

Department of Internal Medicine, the Second People”s Hospital of Jingzhou, Jingzhou, China

国内会议

2015中国老年医学和老年健康产业大会

苏州

英文

336-336

2015-09-11(万方平台首次上网日期,不代表论文的发表时间)