Microarray-Based Analyses in Monocytes of Chinese Uygur Patients with Parkinson”s disease and Cognitive Impairment
OBJECTIVE: The study aimed to identify potential biomarkers associated with Chinese Uygur Parkinson”s disease (PD) with cognitive impairment (PD-CI) in peripheral monocytes.METHODS: We applied gene expression profiling to the study of peripheral monocytes from 3 Chinese Uygur patients with PD-CI and 3 healthy control subjects.Healthy control subjects were matched for age and gender with PD-CI subjects, RNA was extracted from the monocytes samples and the gene expressions were measured using the Illumina HumanHT-12 v4.0 Expression BeadChip, according to the screening criteria of Ratio≥2 and Ratio≤-2.At last, QuantiFast SYBR Green PCR (qRT-PCR) test was performed on samples collected from 31 PD-CI subjects and 35 controls to verify the microarray results.
H.Xia Q.Luo X.Yang
Cadre Health Clinic, Tumor Hospital of Xinjiang Medical University, Urumqi, China
国内会议
苏州
英文
363-363
2015-09-11（万方平台首次上网日期，不代表论文的发表时间）