Sirt3 Expression Alteration in APP/PS1 Double Transgenic Mouse Model of Alzheimer”s Disease

摘要：

BACKGROUND: Alzheimer”s disease is an age-related neurodegenerative disorder, and the underlying mechanisms remain poorly understood.Emerging data has been proposed that mitochondrial dysfunction is one of prominent causes of Alzheimer”s disease (AD) progress.Sirtuin-3 (Sirt3) is a member of sirtuins family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylases, the main mitochondrial lysine deacetylase which regulated a variety of mitochondrial functions and suppressed mitochondrial related physiology in the context of deficiency sirt3.This study aimed to confirm the expression of sirt3 and likely association with sirt3 and mitochondrial dysfunction in AD.

作者: W.X.Yang Y.Lü W.H.Yu

作者单位: Institute of Neuroscience,Chongqing Medical University, Chongqing, China Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing,

会议类型: 国内会议

会议名称: 2015中国老年医学和老年健康产业大会

会议地点: 苏州

会议语种:英文

页码: 364-364

在线出版日期: 2015-09-11（万方平台首次上网日期，不代表论文的发表时间）