Study on the Mechanisms of Vascular Smooth Muscle Cell Senescence and its Effects on Vascular Calcification

摘要：

OBJECTIVE: To explore the mechanisms of vascular smooth muscle cell (VSMC) senescence and its effects on vascular calcification.METHODS: Twenty-four young rats and 24 elderly rats were divided into four groups: normal young group (NY group), young vascular calcification group (Y-VC group), normal elderly group (NE group) and elderly vascular calcification group (E-VC group).The rats were fed for 3 months.Light microscope was used to observe the aorta structure, and Von Kossa staining was used to test vascular calcification;mRNA and protein in aorta osteopontin (OPN), bone morphogenetic protein-2 (BMP-2), p16 and p21 were detected.Serum CRP and serum IL-6 were detected.

作者: S.G.LI W.Shao J.J.Deng D.Zhang M.Ye

作者单位: Department of Geriatrics, Yichang Central People”s Hospital, The First Clinic Medical School of China Three Gorges University

会议类型: 国内会议

会议名称: 2015中国老年医学和老年健康产业大会

会议地点: 苏州

会议语种:英文

页码: 368-368

在线出版日期: 2015-09-11（万方平台首次上网日期，不代表论文的发表时间）