The Anti-vascular Aging Effect of GLP-1 in Arterial Calcification through Attenuating Osteoblastic Differentiation of VSMCs

摘要：

BACKGROUND: Arterial calcification is a common event in cardiovascular pathogenesis.Osteoblastic differentiation of vascular smooth muscle cells (VSMCs) is the most important cytopathologic foundation of arterial calcification.Glucagon-like peptide-1 (GLP-1) exerts multiple cardioprotective actions beyond insulinotropic effects through GLP-1 receptor (GLP-1R).However, whether GLP-1 regulates osteoblastic differentiation of VSMCs and associated molecular mechanisms have not been clarified.

作者: J.K.Zhan Y.J.Wang Y.Wang Z.Y.Tang P.Tan W.Huang Y.S.Liu

作者单位: Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiang-ya Hospital, Central South University,Changsha, Hunan, China

会议类型: 国内会议

会议名称: 2015中国老年医学和老年健康产业大会

会议地点: 苏州

会议语种:英文

页码: 378-378

在线出版日期: 2015-09-11（万方平台首次上网日期，不代表论文的发表时间）