Association of Androgen, Androgen Receptor and AR Gene (CAG)n Repeat Polymorphism with Obesity in Older Males
OBJECTIVE: This paper aimed to investigate androgen, androgen receptor level and AR gene CAG length polymorphism associated with obesity in older males.METHODS: 323 males aged from 60-92 years old were randomly selected from Wanshoulu area,Beijing.Luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and total testosterone (TT) were measured by chemiluminescence technique.Free testosterone (FT), sex hormone binding globulin (SHBG) and dehydroepiandrosterone sulphate (DHEA-s) were measured by ELISA.Mean fluorescent channel (MFC) of androgen receptor in peripheral lymphocyte was analyzed by flow cytometry.DNA sequencing of the CAG repeat from the N-terminal domain of the first exon of the AR gene were analyzed by applied Biosystems 3730xl DNAAnalyzer.
X.M.Chu X.Y.Li C.H.Liang L.Ye J.W.Liu S.Wang H.Zheng F.L.Ma
Department of Cardiovascular Medicine, Beijing Haidian Hospital, Beijing University, Beijing, 100080 Department of Geriatric Cardiology, PLA General Hospital, Beijing 100853, China
国内会议
苏州
英文
21-22
2015-09-11（万方平台首次上网日期，不代表论文的发表时间）