Effects of Fluoxetine on White Matter Changes in a Rat Model of Depression

摘要：

OBJECTIVE: This study aimed to investigate the effects of fluoxetine on white matter changes in a rat model of depression.METHODS: Sprague-Dawley rats were divided into control group, CUS (chronic unpredictable stress, CUS) group and FLX (fluoxetine, FLX) group.After four week chronic unpredictable stress stimulation, the control group and the CUS group rats were treated with saline, and the FLX group rats were treated with fluoxetine at dose of 5 mg/kg/day.The sucrose preference was measured weekly.The white matter volume, the total length and total volume of the myelinated fibers in white matter, the total volume of the myelin sheaths in the white matter were calculated with the stereological methods.

作者: Y.Gao C.X.Huang L.M.Chen Y.Zhang X.Liang J.Tang Q.Xiao Y.Tang

作者单位: Department of Geriatrics, the First Affiliated Hospital, Chongqing Medical University,Chongqing, 400 Department of Histology and Embryology, Chongqing Medical University, Chongqing, 400016, China;Labor Department of Histology and Embryology, Chongqing Medical University, Chongqing, 400016, China;Labor Department of Geriatrics, the First Affiliated Hospital, Chongqing Medical University,Chongqing, 400

会议类型: 国内会议

会议名称: 2015中国老年医学和老年健康产业大会

会议地点: 苏州

会议语种:英文

页码: 173-174

在线出版日期: 2015-09-11（万方平台首次上网日期，不代表论文的发表时间）