Protein Tyrosine Phosphatase SHP-1 Sensitizes EGFR/HER-2 Positive Breast Cancer Cells to Trastuzumab through Modulating Phosphorylation of EGFR and HER-2

摘要：

Objective: Trastuzumab-resistance in HER-2 positive breast caner cells is closely related to both overexpression of EGFR.SHP-1 has been demonstrated to down-regulate tyrosine kinase activity including EGFR via its phosphatase function, but its effect on HER2 activity is still unknown.Here, we examined the hypothesis that SHP-1 enhances the anticancer efficacy of trastuzumab in EGFR/HER-2 positive breast cancer through combining dual inhibition of EGFR and HER-2.

作者: 吴依芬 罗荣城

作者单位: 南方医科大学中西医结合医院;东莞市人民医院肿瘤内科 南方医科大学中西医结合医院肿瘤中心

会议类型: 国内会议

会议名称: 第九届中国肿瘤内科大会、第四届中国肿瘤医师大会暨中国抗癌协会肿瘤临床化疗专业委员会2015年学术年会

会议地点: 北京

会议语种:英文

页码: 688-689

在线出版日期: 2015-07-01（万方平台首次上网日期，不代表论文的发表时间）