Chlorotoxin-Conjugated Nanoparticles for Targeted Imaging and Therapy of Glioma
Glioma is one of the most common malignant brain tumors in adults.Chlorotoxin(CTX)has been identified as a targeting ligand to cross the blood brain barrier(BBB)and specifically bind to glioma.Through different conjugation approaches,CTX can be conjugated onto iron oxide nanoparticles(NPs),quantum dots,or rare-earth upconversion NPs for targeted magnetic resonance or fluorescence imaging of glioma.Likewise,CTX-conjugated NPs can also be used as a carrier system to load radionuclides,anticancer drugs or therapeutic genes for targeted chemotherapy or gene therapy of glioma,respectively.Here we review the recent advances in CTX-targeted NPs for imaging and therapy of glioma.
Chlorotoxin Nanoparticles Glioma Molecular imaging Chemotherapy Gene therapy Radiotherapy
Lingzhou Zhao Jinhua Zhao
Department of Nuclear Medicine,Shanghai General Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200080
国内会议
江苏无锡
英文
82-86
2015-07-03（万方平台首次上网日期，不代表论文的发表时间）