The association between breastfeeding and early childhood caries in children: an update meta-analysis
Background: Epidemiologic studies have yielded inconsistent findings between breastfeeding and risk of early childhood caries(ECC).Objective: We performed a meta-analysis to summarize available evidence from cohort,case-control,and cross-sectional studies of the association between feeding pattern and breastfeeding duration and ECC risk from published observational studies.Design: Studies were identified by searching PubMed,Embase,ISI Web of Science,and the Cochrane Library from 1990 to 2015 August and by reviewing the reference lists of pertinent articles.Random-effects models were used to estimate pooled odds ratios(Ors)using STATA 12.0.Results: 34 studies(9 birth cohorts studies,4 case-control studies and 21 cross-sectional studies)consisting of 64315 children were included.Pooled results from 21 studies found no significant association for ever breastfeeding and ECC compared with never breastfeeding(OR: 0.80; 95%CI: 0.62-1.02,P =0.069)with high evidence of heterogeneity(I2 =85.8%,P<0.001).However,subgroup analysis only found ever breastfeeding could decrease the risk of ECC in the studies of 3-6 years old children(OR= 0.74,95%CI: 0.57-0.98,P =0.034),NOS ≥6(OR =0.66,95%CI: 0.44-0.99,P=0.043),sample size more than 500 subjects(OR=0.67,95%CI:0.47-0.94,P =0.021),published after 2010(OR = 0.47,95%CI:0.25-0.86,P =0.015).Pooled analysis from 15 studies shown that breastfeeding longer than 12 months could increase the risk of ECC compared with breastfeeding shorter than 12 months(OR= 1.91,95%CI: 1.41-2.59,P <0.001)with high evidence of heterogeneity(I2 = 89.9%,P<0.001).Conclusions: Results of this meta-analysis suggest that ever breastfeeding may protect against ECC,and breast-feeding duration longer than 12 months is associated with higher risks of ECC.Additional research is needed to estimate the effect after adjusting for other possible confounding factors.
LingLing Cui Yalan Tian Ling Wang Dongmei Xu Bing Zhao Yan Wang Linyuan Zhao Xiaohuan Zhang WenJie Li
Department of Nutrition and Food Hygiene,College of Public Health,Zhengzhou University,Zhengzhou,Hen Department of Health,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou,Henan,PR China
国内会议
宁夏吴忠
英文
132-147
2015-09-14（万方平台首次上网日期，不代表论文的发表时间）