Mechanisms of Severe Mortality Associated with Bacterial Co-infections following Influenza Infection
Influenza virus infection remains one of the largest disease burdens onhumankind.Influenza-associated bacterial co-infections contribute to severe disease andmortality during pandemic and seasonal influenza episodes.The mechanisms of severemorbidity following such bacterial co-infections mainly include failure of the antibacterialimmune response and synergy of the pathogens.Moreover,the failure of tolerance also isone of the main reasons for excessive mortality,which has been largely overlooked inanimal and human studies.In this review,advances in our understanding of the mechanismsof severe disease associated with bacterial co-infections following influenza virus infectionare discussed.Analysis of these mechanisms should help to develop novel approaches forthe prevention and treatment of influenza virus co-infections.
co-infection influenza bacteria resistance tolerance mortality
Leili Jia Shaofu Qiu Chuanfu Zhang Yuan Liang Hongbin Song
Institute of Disease Control and Prevention,Academy of Military Medical Sciences,Beijing 100071,China
国内会议
吉林延边
英文
1-14
2015-06-10（万方平台首次上网日期，不代表论文的发表时间）