Bisphenol A stimulates human lung cancer cell migration via upregulation of matrix metalloproteinases by GPER/EGFR/ERK1/2 signal pathway
Lung cancer is one of the leading causes of cancer deaths worldwide.Recent evidences indicated that bisphenol A(BPA),a wide contaminant with endocrine disrupting activity,could enhance the susceptibility of carcinogenesis.Although there are increasing opportunities for lung cells exposure to BPA via inhalation,there is no study concerning the effects of BPA on the development of lung cancer.The present study revealed that BPA less than 10à4 M had limited effects on the proliferation of lung cancer A549 cells,however,BPA treatment significantly stimulated the in vitro migration and invasion of cells combing with the morphological changes and up regulation of matrix metalloproteinase-2(MMP-2)and MMP-9.G-protein-coupled estrogen receptor(GPER),while not estrogen receptor a/b(ERa/b),mediated the BPA induced up regulation of MMPs.Further,BPA treatment induced rapid activation of ERK1/2 via GPER/EGFR.GPER/ERFR/ERK1/2 mediated the BPA induced upregulation of MMPs and in vitro migration of lung cancer A549 cells.In summary,our data presented here revealed for the first time that BPA can promote the in vitro migration and invasion of lung cancer cells via upregulation of MMPs and GPER/EGFR/ERK1/2 signals,which mediated these effects.This study suggested that more attention should be paid on the BPA and other possible environmental estrogens induced development of lung cancer.
BPA Lung cancer Migration MMP
Kun-Shui Zhang Hui-Qing Chen Yi-Shen Chen Kai-Feng Qiu Xiao-Bin Zheng Guo-Cheng Li Hai-Di Yang Cui-Ju Wen
Department of Pharmacy,Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 510120,Chin Guangdong Prevention and Treatment Center for Occupational Diseases,Guangzhou 510310,China Department of Pharmacy,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China Department of Respiratory Medicine,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 51 Department of Otolaryngology,Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou 51012
国内会议
广州
英文
1037-1043
2015-12-19（万方平台首次上网日期，不代表论文的发表时间）