Cytokine-induced Killer Cells Enhance the Anti-tumor Effect of Chemotherapy on Patients with Metastatic Breast Cancer
Background and objective: Adoptive transfer of cytokine-induced killer cells (CIK cells) provides a potentially powerful treatment for cancer.The combination of CIKs and chemotherapy these two therapy holds great promise for the treatment of advanced breast cancer.Methods: Eighty-six patients with advanced breast cancer were enrolled in the study between Jan 2007 and Dec 2011, among whona 43 were in chemotherapy + CIK cells group, 43 in chemotherapy alone group.CIK cells were infused intravenously before the second cycle of chemotherapy.Results: The disease control rate had no significant difference (P=0.016).The time to progression of the combination group was 6.8 months which was significantly longer than the 4.7 months in the chemotherapy alone group (P =0.012).The overall survival had no significant difference between the two groups (P=0.573).The CIK cells infusion had no additional adverse effect.Conclusion: Autologous CIK cells cell transfusion in combination with chemotherapy might have survival benefit for the patients with advanced breast cancer.
邵彬 李惠平
北京肿瘤医院乳腺肿瘤内科
国内会议
第八届中国肿瘤内科大会、第三届中国肿瘤医师大会暨中国抗癌协会肿瘤临床化疗专业委员会2014年学术年会
北京
英文
595-595
2014-07-02（万方平台首次上网日期，不代表论文的发表时间）