Cisplatin/tetrandrine Co-loaded Nanoparticles Effectively Promote the Antitumor Effect of the Two Drugs in vitro and in vivo

摘要：

Co-delivery of antitumor agents has a potential to efficaciously treat human diseases via their synergetic effects.In this report, we prepared nanoparticles (NPs) for co-delivery of cisplatin (CDDP), a widely used chemotherapeutics and tetrandrine (Tet), an alkaloid isolated from the Chinese herb using PEG-PCL/PCL copolymer hybrid.By w/o/w double emulsion method, CDDP and Tet were incorporated into the NPs with the loading content of 3.32％ and 7.45％ respectively.In vitro studies showed that drugs loaded in NPs enter LoVo cells by cellular uptake of NPs.On three different cancer cell lines.

作者: 李茹恬 刘芹 李晓林 禹立霞 钱晓萍 刘宝瑞

作者单位: The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University

会议类型: 国内会议

会议名称: 第八届中国肿瘤内科大会、第三届中国肿瘤医师大会暨中国抗癌协会肿瘤临床化疗专业委员会2014年学术年会

会议地点: 北京

会议语种:英文

页码: 712-712

在线出版日期: 2014-07-02（万方平台首次上网日期，不代表论文的发表时间）