Analysis of PDGFRA Mutations in 351 Chinese Melanomas and Evaluation of Their Sensitivity to Tyrosine Kinase Inhibitors Imatinib and Crenolanib

摘要：

PDGFRα is a target for tyrosine kinase inhibitors(TKIs)-based targeted therapy.Dysregulation of PDGFRα has been reported in many cancers.However, PDGFRA mutations in melanomas have not been well studied.We analyzed the genetic mutations of PDGFRA in Chinese melanoma patients, and determined the inhibitory potency of TKIs such as imatinib and crenolanib on mutant PDGFRA.351 melanoma tissue samples were examined for genetic mutations in exons 12, 14 and 18 of PDGFRA by PCR amplification and Sanger sequencing.PDGFRA mutations were observed in 4.6％(16/351)of melanomas.

作者: Jie Dai Yan Kong Xiaowei Xu Lu Si Zhihong Chi Chuanliang Cui Xinan Sheng Ruifeng Yang Shujing Liu Jun Guo

作者单位: Department of Renal cancer and Melanoma, Peking University School of Oncology, Beijing Cancer Hospit Department of Pathology and Laboratory Medicine, Abramson Cancer Center of the University of Pennsyl

会议类型: 国内会议

会议名称: 第十六届全国临床肿瘤学大会暨2013年CSCO学术年会

会议地点: 厦门

会议语种:英文

页码: 122-122

在线出版日期: 2013-09-25（万方平台首次上网日期，不代表论文的发表时间）