Hepatoprotective effects of tocotrienols on lipid peroxidation, antioxidant scavenging enzymes, and PPAR expression in the liver of high-fat diet-fed mice
Scope Prolonged consumption of high fat diet primarilyaffects the liver thru the production of ROS that causes oxidative stress.Tocotrienols are antioxidants belonging to the vitamin E group.However, evaluation of tocotrienó1s physiological effects is very few compared to tocopherols.This study evaluated the hepatoprotective effects of tocotrienols on the liver of high fat diet-fed mice.Specifically, its effect on lipid peroxidation, antioxidant scavenging enzymes and expression of PPAR α and γ were analysed.Methods and Results Kunming mice wereuniformly divided into 6 groups.The first group served as normal control while the second group served as high-fat group.Group 3 served as 2nd normal control given with tocotrienol (200mg/(kg · day)).Groups 4,5 ,and 6 served as treatment groups given with high fat diet and different doses of tocotrienols (200,100, and 50 mg/(kg · day), respectively).Tocotrienols greatly reduced lipid peroxidation while influences the total antioxidant capacity of the liver.It also increased antioxidant scavenging enzymes and increased the expression of PPAR α and γ.Conclusion Fat accumulation in the liver can initiate chains of events the negatively affects its integrity.However, tocotrienols, as a hepatoprotective compound, acts in more ways than one.It not only counteracts oxidants but also helps in the expression of other oxidant-neutralizing compounds and genes that help regulate the cells metabolism.
Tocotrienol lipid peroxidation antioxidant scavenging enzymes PPAR hypercholesterolemia
Froilan Bernard R.Matias Qiong WEN Zijiu WANG Haibin HUANG Jing WU Lixin WEN
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, Hunan Agricultural Unive Department of Veterinary Clinical Medicine, College of Veterinary Medicine, Hunan Agricultural Unive Department of Veterinary Clinical Medicine, College of Veterinary Medicine, Hunan Agricultural Unive
国内会议
昆明
英文
83-90
2014-07-19（万方平台首次上网日期，不代表论文的发表时间）