Activation of Liver X Receptor Induces Macrophage Interleukin-5 Expression
Interleukin-5 (IL-5) stimulates production of T15/EO6 IgM antibodies that can block the uptake of oxidized low density lipoprotein bymacrophages, whereas a deficiency in macrophage IL-5 expression accelerates development of atherosclerosis.Liver X receptor (LXR) are ligand-activated transcription factors that can induce macrophage ABCA1 expression and cholesterol efflux, thereby inhibiting the development of atherosclerosis.However, it remains unknown whether additional mechanisms, such as the regulation of macrophage IL-5 expression, are related to the anti-atherogenic properties of LXR.
Interleukin-5 Liver X Receptor Macrophage IgM Atherosclerosis
Yuan-Li Chen Ji-Hong Han Ya-Jun Duan
The State Key Laboratory of Medicinal Chemical Biology and the College of Life Sciences, Nankai University, Tianjin 300071, China
国内会议
江苏苏州
英文
67-67
2013-10-11（万方平台首次上网日期，不代表论文的发表时间）