DNA Topoisomerase Ⅱ Inhibitors Induce Macrophage ABCA1 Expression and Cholesterol Efflux: New Function of Topoisomerase Ⅱ

摘要：

ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux and thereby inhibits lipid-laden macrophage/foam cell formation and atherosclerosis.ABCA1 expression is transcriptionally regulated by activation of liver X receptor (LXR).Both etoposide and teniposide are DNA topoisomerase Ⅱ (Topo Ⅱ) inhibitors and are chemotherapeutic medications used in the treatment of various cancers.

关键词： ABCA1 Atherosclerosis Topoisomerase Ⅱ Inhibitor LXR Macrophage

作者: Ya-Jun Duan Ling Zhang Ji-Hong Han

作者单位: The State Key Laboratory of Medicinal Chemical Biology and the College of Life Sciences, Nankai University, Tianjin 300071, China

会议类型: 国内会议

会议名称: 第十二次全国动脉硬化性疾病学术会议

会议地点: 江苏苏州

会议语种:英文

页码: 67-68

在线出版日期: 2013-10-11（万方平台首次上网日期，不代表论文的发表时间）