Toll-like Receptor (TLR) 2 Mediates Inflammatory Responses to the Hemorrhagic Co1i Pilus (HCP) of E.coli O157∶H7
Enterohemorrhagic Escherichia coli (EHEC) O157∶H7 infections are associated with hemorrhagic colitis and the hemolytic-uremic syndrome (HUS).EHEC O157∶H7 produces long bundles of type ⅣV pili (TFP) called hemorrhagic coli pili (HCP).HCP are multipurpose structures with pathogenic attributes, and they mediate i) adherence to human and bovine epithelial cells;ii)invasion of epithelial cells;iii) hemagglutination of rabbit erythrocytes;iv) biofilm formation;v) twitching motility;and vi) release of proinflammatory factors.However, the detailed pathogenic mechanisms of HCP still do not study clearly.
Zhang Xuehan Zhang Bicheng Sun Xiaohan He Kongwang
Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences;Key Laboratory of Engineering Research of Veterinary Bio-products of Agricultural Ministry;National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014 China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou, 225009 China;Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Nanjing 210014 China
国内会议
2016第六届中国兽药大会(中国畜牧兽医学会动物药品学分会第五届全国会员代表大会暨2016学术年会、中国微生物学会兽医微生物学专业委员会、中国畜牧兽医学会生物制品学分会2016年联合学术大会)
成都
英文
67-68
2016-09-01（万方平台首次上网日期，不代表论文的发表时间）