The Role of microRNAs in Alzheimer”s Disease and Stroke

摘要：

Polygenetic risk factors and reduced expression of many genes in late-onset Alzheimer”s disease (AD) impedes identification of a target(s) for disease-modifying therapies.We identified a single microRNA, miR-34a that is over expressed in specific brain regions of AD patients as well as in the 3xTg-AD mouse model.Specifically, increased miR-34a expression in the temporal cortex region compared to age matched healthy control correlates with severity of AD pathology.

作者: James W Simpkins

作者单位: Center for Basic & Translational Stroke Research,West Virginia University School of Medicine, USA

会议类型: 国内会议

会议名称: 2016‘’国际老年健康论坛·泰山

会议地点: 山东泰安

会议语种:英文

页码: 127-127

在线出版日期: 2016-09-23（万方平台首次上网日期，不代表论文的发表时间）