Targeting Phosphodiesterase Signaling for Aging Related Emotional and Cognitive Disorders
The major factors involved in the age-related cognitive decline and mood disorders remain to be specified, but there is significant evidence indicating that chronic stress and neuronal vulnerability are interrelated events contributing to age-related pathologies.A potential therapeutic for these stress related disturbances is through mediation of phosphodiesterase 2 (PDE2), an enzyme that exerts its action on cognitive processes via the control of intracellular second messengers, cGMPand cAMP.
Ying Xu
School of Pharmacy & Pharmaceutical Sciences University at Buffalo, The State University of New York, USA
国内会议
山东泰安
英文
128-128
2016-09-23（万方平台首次上网日期，不代表论文的发表时间）