The Senescent Synapse
Increased human longevity has magnified the negative impact that aging can have on cognitive integrity of older individuals experiencing some decline in cognitive function.Brain regions that are vulnerable to aging exhibit the earliest pathology of Alzheimer”s disease (AD).Senescent synaptic function is observed as a shift in Ca2+-dependent synaptic plasticity and similar mechanisms are thought to contribute to the early cognitive deficits associated with AD.In the case of aging, intracellular redox state mediates a shift in Ca2+ regulation including N-methyl-D-aspartate (NMDA) receptor hypofunction and increased Ca2+ release from intracellular stores to alter synaptic plasticity.
Thomas C.Foster
Neuroscience at the University of Florida
国内会议
山东泰安
英文
129-129
2016-09-23（万方平台首次上网日期，不代表论文的发表时间）