Effect of ABCB1 rs12720464 and rs1055302 polymorphisms in Chinese patients on the time-course of action of rocuronium administered as a single dose
Objective: To determine whether ABCB11 gene polymorphisms affect the time-course of action of rocuronium in Chinese patients.Methods: This study included 105 unrelated Chinese patients undergoing general anesthesia with propofol, fentanyl and rocuronium.Neuromuscular monitoring was performed with calibrated acceleromyography.Patients were allowed to recover spontaneously from the neuromuscular block.The time interval between the first maximum depression of the train of four (TOF) and spontaneous recovery TOF ratio of 0.25/0.7/0.8/0.9 was recorded.The Sequenom MassArray(R) SNP detection technology was used to detect the genotypes of the ABCB1 rs12720464, rs1055302.Demographic and non-genetic clinical data were also collected.Results: In the present study, the mean time to spontaneous recovery of TOF ratio 0.8/0.9 in ABCB1 rs12720464 GG genotype was longer compared to that observed in ABCB1 rs12720464 AG genotype (56.77 ±14.23 min vs.49.50 ±10.49 min, and 62.58 ±18.16 min vs.53.20 ±12.56 min, respectively, P<0.05).Further, the time to spontaneous recovery of TOF 0.7/0.8/0.9 in ABCB1 rs1055302 GG genotype was longer than that in ABCB1 rs1055302 AG genotype (52.00 ±12.10 min vs.44.83 ±7.38 min,55.96 ±13.92 min vs.46.83 ±7.67 min, 61.66 ±17.70 min vs.49.50 ±8.44 min, respectively,P<0.05).Conclusion: In Chinese patients administered a single-dose rocuronium, the genetic variants ABCB1 rs12720464, and rs1055302 contribute to the individual variability of time-course of action.Clinical trial registration number: ChoCTR-PRP-15007205.
ABCB1 Genetic polymorphisms Rocuronium
Tian-long Qi Yin-hui Zhou Jing-jing Yuan Zhi-song Li Zhong-yu Wang Yan-zi Chang Er-xian Zhao Dan Cheng Jun-kai Hou Yan Tian Ge-zi Chen Yuan-yuan Mao Yang Ren Li-rong Zhang Quan-cheng Kan Wei Zhang
Anesthesiology department in the first affiliated hospital of Zhengzhou University,Zhengzhou,Henan,C Department of Pharmacology,School of Medicine,Zhengzhou,China Clinical pharmacology base,the open key clinical medical experimental laboratory institute of Henan
国内会议
中国药理学会麻醉药理专业委员会第七次全国学术年会暨甘肃省医师协会麻醉医师分会成立大会
兰州
英文
1-27
2016-07-01（万方平台首次上网日期，不代表论文的发表时间）