Sc(OTf)3-catalyzed three-component cascade reaction: one-pot synthesis of substituted 3-oxoisoindoline-1-carbonitrile derivatives

摘要：

　　A facile and efficient approach for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives has been developed, with a Sc(OTf)3-catalyzed three-component Strecker/ Lactamization cascade reaction involving methyl 2-formylbenzoate, TMSCN and amines in ethanol at room temperature.Good to excellent yields for a broad scope of amine substrates were achieved.

关键词： Isoindolinones Cascade reaction Amines Sc(OTf)3

作者: Tingting Chen Chun Cai

作者单位: Chemical Engineering College, Nanjing University of Science & Technology, 200 Xiaolingwei, Nanjing 210094, P.R.China

会议类型: 国内会议

会议名称: 2016年全国功能精细化学品绿色制造及应用技术交流会

会议地点: 南京

会议语种:英文

页码: 15-20

在线出版日期: 2016-12-06（万方平台首次上网日期，不代表论文的发表时间）